OBI coined this phase “Cell Culture Compatible” to describe a transdermal delivery system which allows an active ingredient, or more importantly a finished formulation, to also be directly placed on “naked “ human cell cultures of keratinocytes, melanocytes and fibroblasts.
This requires the delivery system to possess a very low cytotoxicity and be of a particle size that allows both transdermal delivery (i.e. < 600 angstroms) and be viewed by the cells in the in vitro cell culture or in vivo intact skin as food. Thus, the critical importance of our bio-emulsifiers and selective enzyme release ingredients.
Termed Chylosome technology because it mimics the natural chylomicrons found in the body for delivery of nutritional ingredients to cells, these systems allow for a cost effective method of screening new ingredients and products which offer maximum proliferative augmentation with minimal irritation potential.
The ability to apply Omega 36 lipid arms to any Vitamin or bio-active molecule to produce a pro-vitamin or prodrug, allows optimized entry, low irritation and the use of very high concentrations of vitamins in a BioEster system for topical delivery.
